PUM3 Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress. Binds to double-stranded RNA or DNA without sequence specificity. Involved in development of the eye and of primordial germ cells. Widely expressed. Note: This description may include information from UniProtKB.
Protein type: Endoplasmic reticulum; Nucleolus; RNA-binding
Chromosomal Location of Human Ortholog: 1q52
Cellular Component:  chromosome; endoplasmic reticulum; nucleolus; nucleoplasm
Molecular Function:  DNA binding; RNA binding
Biological Process:  regulation of protein ADP-ribosylation
Reference #:  Q562C7 (UniProtKB)
Alt. Names/Synonyms: LOC499339; Pum3; Pumilio homolog 3; pumilio RNA-binding family member 3
Gene Symbols: Pum3
Molecular weight: 72,786 Da
Basal Isoelectric point: 9.7  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein