PDE4A Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily. Isoform 1 is widely expressed. Isoform 2 is abundant in liver, stomach, testis, thyroid and adrenal glands. It is also found in placenta, kidney, pancreas, ovary, uterus, skin, monocytes, mast cells, macrophages, as well as in bronchial smooth muscle. Isoform 6 is expressed at high levels in the heart and small intestine. It is also found in the brain, kidney, spleen, colon, salivary gland, ovary and peripheral blood lymphocytes. Isoform 7 is expressed predominantly in skeletal muscle and brain and at lower levels in the testis. Isoform 7 is expressed in the brain. Found in specific neuronal subpopulations in cortex, spinal cord and cerebellum (at protein level). 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component:  cytosol; membrane; nucleoplasm; perinuclear region of cytoplasm; plasma membrane; ruffle membrane
Molecular Function:  3',5'-cyclic-AMP phosphodiesterase activity; cAMP binding; metal ion binding; protein binding
Biological Process:  cAMP catabolic process; cellular response to drug; G protein-coupled receptor signaling pathway; regulation of cAMP-mediated signaling; regulation of protein kinase A signaling; sensory perception of smell; signal transduction
Reference #:  P27815 (UniProtKB)
Alt. Names/Synonyms: cAMP-specific 3',5'-cyclic phosphodiesterase 4A; cAMP-specific phosphodiesterase; DPDE2; PDE4; PDE46; PDE4A; phosphodiesterase 4A; phosphodiesterase 4A, cAMP-specific (dunce; phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila); phosphodiesterase E2 dunce homolog, Drosophila; phosphodiesterase isozyme 4
Gene Symbols: PDE4A
Molecular weight: 98,143 Da
Basal Isoelectric point: 5.09  Predict pI for various phosphorylation states
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PDE4A

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein