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ST8SIA1
Involved in the production of gangliosides GD3 and GT3 from GM3; gangliosides are a subfamily of complex glycosphinglolipds that contain one or more residues of sialic acid. Belongs to the glycosyltransferase 29 family. Strongly expressed in melanoma cell lines, adult and fetal brain and to a lesser extent in adult and fetal lung. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.4.99.8; Glycan Metabolism - glycosphingolipid biosynthesis - ganglio series; Glycan Metabolism - glycosphingolipid biosynthesis - globo series; Glycan Metabolism - glycosphingolipid biosynthesis - lacto and neolacto series; Membrane protein, integral; Transferase |
| Chromosomal Location of human Ortholog: 12p12.1 |
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Cellular Component:
Golgi membrane; membrane
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Molecular Function:
alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity; protein binding; sialyltransferase activity
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Biological Process:
carbohydrate metabolic process; cellular response to heat; epithelial cell proliferation; glycosphingolipid biosynthetic process; N-glycan processing; oligosaccharide metabolic process; positive regulation of epithelial cell proliferation; protein glycosylation
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Reference #:
Q92185
(UniProtKB)
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Alt. Names/Synonyms: Alpha-2,8-sialyltransferase 8A; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; disialoganglioside (GD3) synthase; Ganglioside GD3 synthase; Ganglioside GT3 synthase; ganglioside-specific alpha-2,8-polysialyltransferase; GD3S; SIA8A; sialyltransferase 8 (alpha-N-acetylneuraminate: alpha-2,8-sialytransferase, GD3 synthase) A; Sialyltransferase 8A; sialyltransferase 8A (alpha-N-acetylneuraminate: alpha-2,8-sialyltransferase, GD3 synthase); Sialyltransferase St8Sia I; Sialytransferase St8Sia I; SIAT8; SIAT8-A; SIAT8A; ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1; ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 1; ST8SIA1; ST8SiaI
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Gene Symbols: ST8SIA1
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Molecular weight:
40,519 Da
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Basal Isoelectric point:
9.41
Predict pI for various phosphorylation states
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