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Cortactin
Contributes to the organization of the actin cytoskeleton and cell shape. Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones. Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density. Plays a role in the invasiveness of cancer cells, and the formation of metastases. Plays a role in focal adhesion assembly and turnover. In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement. Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane. Plays a role in receptor-mediated endocytosis via clathrin-coated pits. Required for stabilization of KCNH1 channels at the cell membrane. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis |
| Chromosomal Location of Human Ortholog: 11q13.3 |
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Cellular Component:
cell cortex; clathrin-coated pit; cortical cytoskeleton; cytoplasm; cytoskeleton; cytosol; dendritic spine; Golgi apparatus; intracellular membrane-bounded organelle; lamellipodium; mitotic spindle midzone; plasma membrane; podosome; ruffle
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Molecular Function:
profilin binding; protein binding
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Biological Process:
actin cytoskeleton reorganization; actin filament polymerization; cell motility; dendritic spine maintenance; focal adhesion assembly; intracellular protein transport; lamellipodium organization; membrane organization; negative regulation of extrinsic apoptotic signaling pathway; neuron projection morphogenesis; positive regulation of actin filament polymerization; positive regulation of smooth muscle contraction; receptor-mediated endocytosis; regulation of autophagy of mitochondrion; regulation of axon extension; substrate-dependent cell migration, cell extension
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Reference #:
Q14247
(UniProtKB)
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Alt. Names/Synonyms: 1110020L01Rik; Amplaxin; cortactin; CTTN; EMS1; ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate); epididymis secretory sperm binding protein; FLJ34459; Oncogene EMS1; Src substrate cortactin; SRC8
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Gene Symbols: CTTN
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Molecular weight:
61,586 Da
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Basal Isoelectric point:
5.24
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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Adherens Junction Dynamics
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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