K2 a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 12q13.13
Cellular Component:  cornified envelope; cytosol; intermediate filament; keratin filament
Molecular Function:  cytoskeletal protein binding; protein binding; structural constituent of cytoskeleton; structural constituent of epidermis
Biological Process:  cornification; epidermis development; intermediate filament organization; keratinization; keratinocyte activation; keratinocyte development; keratinocyte migration; keratinocyte proliferation; peptide cross-linking; positive regulation of epidermis development
Disease: Ichthyosis, Bullous Type
Reference #:  P35908 (UniProtKB)
Alt. Names/Synonyms: CK-2e; Cytokeratin-2e; epidermal ichthyosis bullosa of Siemens; Epithelial keratin-2e; K22E; K2e; keratin 2; Keratin, type II cytoskeletal 2 epidermal; Keratin-2 epidermis; Keratin-2e; KRT2; KRT2A; KRT2E; KRTE; MGC116967; MGC116968; Type-II keratin Kb2
Gene Symbols: KRT2
Molecular weight: 65,433 Da
Basal Isoelectric point: 8.07  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene