POLRMT
DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the phage and mitochondrial RNA polymerase family. Note: This description may include information from UniProtKB.
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Protein type: EC 2.7.7.6; Mitochondrial; Transcription initiation complex; Transferase |
Chromosomal Location of human Ortholog: 19p13.3 |
Cellular Component:
mitochondrial DNA-directed RNA polymerase complex; mitochondrial matrix; mitochondrial nucleoid; mitochondrion; protein-containing complex
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Molecular Function:
3'-5'-RNA exonuclease activity; DNA primase activity; DNA-directed 5'-3' RNA polymerase activity; mitochondrial promoter sequence-specific DNA binding; protein binding; sequence-specific DNA binding
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Biological Process:
DNA replication, synthesis of RNA primer; mitochondrial transcription; transcription initiation at mitochondrial promoter
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Disease: Combined Oxidative Phosphorylation Deficiency 55
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Reference #:
O00411
(UniProtKB)
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Alt. Names/Synonyms: APOLMT; DNA-directed RNA polymerase, mitochondrial; h-mtRPOL; MTRNAP; MtRPOL; POLRMT; polymerase (RNA) mitochondrial (DNA directed); RNA polymerase mitochondrial; RPOM
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Gene Symbols: POLRMT
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Molecular weight:
138,620 Da
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Basal Isoelectric point:
9.19
Predict pI for various phosphorylation states
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