POLRMT DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the phage and mitochondrial RNA polymerase family. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.7.6; Mitochondrial; Transcription initiation complex; Transferase
Chromosomal Location of human Ortholog: 19p13.3
Cellular Component:  mitochondrial DNA-directed RNA polymerase complex; mitochondrial matrix; mitochondrial nucleoid; mitochondrion; protein-containing complex
Molecular Function:  3'-5'-RNA exonuclease activity; DNA primase activity; DNA-directed 5'-3' RNA polymerase activity; mitochondrial promoter sequence-specific DNA binding; protein binding; sequence-specific DNA binding
Biological Process:  DNA replication, synthesis of RNA primer; mitochondrial transcription; transcription initiation at mitochondrial promoter
Disease: Combined Oxidative Phosphorylation Deficiency 55
Reference #:  O00411 (UniProtKB)
Alt. Names/Synonyms: APOLMT; DNA-directed RNA polymerase, mitochondrial; h-mtRPOL; MTRNAP; MtRPOL; POLRMT; polymerase (RNA) mitochondrial (DNA directed); RNA polymerase mitochondrial; RPOM
Gene Symbols: POLRMT
Molecular weight: 138,620 Da
Basal Isoelectric point: 9.19  Predict pI for various phosphorylation states
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POLRMT

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein