CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 is a cell-cell adhesion molecule that that mediates homophilic cell adhesion in a calcium-independent manner. Has tumor suppressor activity in prostate carcinoma. Plays a role in insulin action and angiogenesis, and is a coinhibitory receptor of T cells, natural killer (NK) and neutrophils. Inhibits TCR-mediated cytotoxicity upon TCR/CD3 complex stimulation by blocking granule exocytosis. Inhibits T cell proliferation and cytokine production. Regulates autoimmunity and anti-tumor immunity by inhibiting T cell through its interaction with HAVCR2. Upon natural killer (NK) cells activation, inhibit KLRK1-mediated cytolysis of CEACAM1-bearing tumor cells by trans-homophilic interactions with CEACAM1 on the target cell and lead to cis-interaction between CEACAM1 and KLRK1. Inhibits IL1B production by upon neutrophils activation. Downregulates neutrophil production by acting as a coinhibitory receptor for CSF3R. directly associates with annexin II. Regulates insulin action by promoting INS clearance and regulating lipogenesis in liver through regulating insulin signaling. Functions as activator in angiogenesis by promoting blood vessel remodeling through endothelial cell differentiation and migration and in arteriogenesis by increasing the number of collateral arteries and collateral vessel calibers after ischemia. Regulates vascular permeability through the VEGFR2 signaling pathway resulting in control of nitric oxide production. Belongs to the immunoglobulin superfamily. CEA family. Expressed in columnar epithelial cells of the colon. Belongs to the immunoglobulin superfamily and the CEA family. Abundantly expressed in epithelia, vessel endothelia, trophoblasts, B cells, T cells, NK cells, macrophages, dendritic cells, platelets and neutrophilic granulocytes. Eleven alternatively spliced human isoforms have been described. Eight (isoforms 1, 5-11) are type I membrane proteins, while three (isoforms 2-4) are secreted. The short form (Isoform 7) promotes populations of T cells regulating IgA production and secretion associated with control of the commensal microbiota and resistance to enteropathogens. The predominant forms expressed by T cells are those containing a long cytoplasmic domain (isoforms 1, 5, 6 and 7). Expressed in granulocytes and lymphocytes. Leukocytes only express isoforms 6 and isoform 1. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 7 A3|7 13.84 cM
Cellular Component:  adherens junction; apical plasma membrane; basal plasma membrane; brush border membrane; cell junction; cell projection; cell surface; cell-cell junction; ciliary membrane; cytoplasmic vesicle; external side of plasma membrane; extracellular space; integral component of membrane; lateral plasma membrane; membrane; plasma membrane
Molecular Function:  actin binding; bile acid transmembrane transporter activity; calmodulin binding; filamin binding; granulocyte colony-stimulating factor receptor binding; identical protein binding; kinase binding; protein binding; protein dimerization activity; protein homodimerization activity; protein kinase binding; protein phosphatase binding; protein tyrosine kinase binding; Toll-like receptor binding; virion binding; virus receptor activity
Biological Process:  blood vessel development; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; cell-cell junction organization; common myeloid progenitor cell proliferation; granulocyte colony-stimulating factor signaling pathway; homophilic cell adhesion via plasma membrane adhesion molecules; insulin catabolic process; negative regulation by host of viral genome replication; negative regulation by host of viral process; negative regulation of bone resorption; negative regulation of cytokine production; negative regulation of granulocyte differentiation; negative regulation of hepatocyte proliferation; negative regulation of interleukin-1 production; negative regulation of interleukin-2 production; negative regulation of JNK cascade; negative regulation of lipid biosynthetic process; negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; negative regulation of osteoclast differentiation; negative regulation of platelet aggregation; negative regulation of protein kinase activity; negative regulation of T cell proliferation; negative regulation of vascular permeability; Peyer's patch development; positive regulation by host of viral process; positive regulation of activation-induced cell death of T cells; positive regulation of calcineurin-NFAT signaling cascade; positive regulation of CD4-positive, alpha-beta T cell activation; positive regulation of CD4-positive, alpha-beta T cell proliferation; positive regulation of CD8-positive, alpha-beta T cell activation; positive regulation of immunoglobulin secretion; positive regulation of JNK cascade; positive regulation of MAP kinase activity; positive regulation of T cell proliferation; positive regulation of vasculogenesis; regulation of blood vessel remodeling; regulation of endothelial cell differentiation; regulation of endothelial cell migration; regulation of epidermal growth factor receptor signaling pathway; regulation of sprouting angiogenesis; viral entry into host cell; viral process
Reference #:  P31809 (UniProtKB)
Alt. Names/Synonyms: bb-1; Bgp; BGP-1; Bgp1; Bgpd; Biliary glycoprotein 1; Biliary glycoprotein D; C-CAM; carcinoembryonic antigen 1; carcinoembryonic antigen 7; Carcinoembryonic antigen-related cell adhesion molecule 1; Cc1; CD66a; Cea-1; Cea-7; CEA-related cell adhesion molecule 1; Cea1; Cea7; Ceacam1; CEAM1; hepatitis virus (MHV-4) susceptibility; hepatitis virus receptor; Hv-2; Hv2; mCEA1; Mhv-1; MHV-R; MHVR; MHVR1; mmCGM1; mmCGM1a; mmCGM2; Murine hepatitis virus receptor
Gene Symbols: Ceacam1
Molecular weight: 57,016 Da
Basal Isoelectric point: 5.35  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CEACAM1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene