TLL2 Protease which specifically processes pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.24.-; Protease; Secreted; Secreted, signal peptide
Chromosomal Location of human Ortholog: 10q24.1
Cellular Component:  extracellular region
Molecular Function:  calcium ion binding; metalloendopeptidase activity; zinc ion binding
Biological Process:  cell differentiation; extracellular matrix disassembly; multicellular organism development; negative regulation of skeletal muscle tissue growth; proteolysis
Reference #:  Q9Y6L7 (UniProtKB)
Alt. Names/Synonyms: KIAA0932; MGC133312; MGC133313; TLL2; tolloid like 2; tolloid-like 2; Tolloid-like protein 2
Gene Symbols: TLL2
Molecular weight: 113,557 Da
Basal Isoelectric point: 5.6  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene