Siva a proapoptotic protein. Associates with CD27, a member of the tumor necrosis factor receptor family. Two alternatively spliced isoforms have been described. Isoform 1 but not isoform 2 may induce TNFRSF7/CD27 mediated apoptosis. Isoform 1 inhibits Bcl-xL anti-apoptotic activity. Note: This description may include information from UniProtKB.
Protein type: Apoptosis
Chromosomal Location of Human Ortholog: 14q32.33
Cellular Component:  cytoplasm; nucleoplasm
Molecular Function:  CD27 receptor binding; metal ion binding; protein binding; tumor necrosis factor receptor binding; virus receptor activity
Biological Process:  extrinsic apoptotic signaling pathway; viral entry into host cell
Reference #:  O15304 (UniProtKB)
Alt. Names/Synonyms: Apoptosis regulatory protein Siva; CD27-binding (Siva) protein; CD27-binding protein; CD27BP; SIVA; Siva-1; Siva-2; SIVA1; SIVA1, apoptosis-inducing factor
Gene Symbols: SIVA1
Molecular weight: 18,695 Da
Basal Isoelectric point: 7.86  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein