separase a caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms. Regulated by at least two independent mechanisms. First, it is inactivated via its interaction with securin/PTTG1, which probably covers its active site. Second, phosphorylation inactivates it. It is completely phosphorylated during mitosis and dephosphorylated during anaphase. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC; Protease
Chromosomal Location of Human Ortholog: 12q13.13
Cellular Component:  centrosome; cytosol
Molecular Function:  catalytic activity; cysteine-type peptidase activity; protein binding
Biological Process:  apoptotic process; establishment of mitotic spindle localization; homologous chromosome segregation; meiotic spindle organization; mitotic cytokinesis; mitotic sister chromatid segregation; negative regulation of sister chromatid cohesion; positive regulation of mitotic metaphase/anaphase transition; proteolysis
Reference #:  Q14674 (UniProtKB)
Alt. Names/Synonyms: Caspase-like protein ESPL1; ESP1; ESPL1; extra spindle pole bodies homolog 1 (S. cerevisiae); extra spindle poles like 1; Extra spindle poles-like 1 protein; FLJ46492; KIAA0165; Separase; Separin
Gene Symbols: ESPL1
Molecular weight: 233,175 Da
Basal Isoelectric point: 7.65  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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