separase Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Protease
Chromosomal Location of Human Ortholog: 12q13.13
Cellular Component:  centrosome; cytosol
Molecular Function:  catalytic activity; cysteine-type peptidase activity; protein binding
Biological Process:  apoptotic process; establishment of mitotic spindle localization; homologous chromosome segregation; meiotic spindle organization; mitotic cytokinesis; mitotic sister chromatid segregation; negative regulation of sister chromatid cohesion; positive regulation of mitotic metaphase/anaphase transition; proteolysis
Reference #:  Q14674 (UniProtKB)
Alt. Names/Synonyms: Caspase-like protein ESPL1; ESP1; ESPL1; extra spindle pole bodies homolog 1 (S. cerevisiae); extra spindle poles like 1; Extra spindle poles-like 1 protein; FLJ46492; KIAA0165; Separase; Separin
Gene Symbols: ESPL1
Molecular weight: 233,175 Da
Basal Isoelectric point: 7.65  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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