neurogenin 1 Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 5q31.1
Cellular Component:  nucleus; perikaryon
Molecular Function:  chromatin binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; E-box binding; protein binding; protein homodimerization activity; sequence-specific double-stranded DNA binding
Biological Process:  auditory behavior; cell fate commitment; cochlea development; cochlea morphogenesis; craniofacial suture morphogenesis; genitalia development; genitalia morphogenesis; hard palate morphogenesis; inner ear development; inner ear morphogenesis; learned vocalization behavior; mastication; negative regulation of relaxation of muscle; negative regulation of saliva secretion; nervous system development; neuromuscular process controlling balance; neuron differentiation; peristalsis; positive regulation of DNA-binding transcription factor activity; positive regulation of exit from mitosis; positive regulation of neuron differentiation; positive regulation of transcription by RNA polymerase II; regulation of muscle organ development; regulation of transcription by RNA polymerase II; thorax and anterior abdomen determination; trigeminal nerve development; vestibulocochlear nerve formation
Reference #:  Q92886 (UniProtKB)
Alt. Names/Synonyms: AKA; BHLHA6; Class A basic helix-loop-helix protein 6; Math4C; NEUROD3; NEUROG1; Neurogenic basic-helix-loop-helix protein; neurogenic differentiation 3; Neurogenic differentiation factor 3; neurogenin 1; Neurogenin-1; NGN; NGN-1; NGN1
Gene Symbols: NEUROG1
Molecular weight: 25,718 Da
Basal Isoelectric point: 6.9  Predict pI for various phosphorylation states
Select Structure to View Below

neurogenin 1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene