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PFKFB2
Synthesis and degradation of fructose 2,6-bisphosphate. In the C-terminal section; belongs to the phosphoglycerate mutase family. Heart. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; EC 3.1.3.46; Kinase, other; Motility/polarity/chemotaxis; Phosphatase (non-protein) |
| Chromosomal Location of human Ortholog: 1q32.1 |
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Cellular Component:
cytosol; nucleoplasm
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Molecular Function:
6-phosphofructo-2-kinase activity; ATP binding; fructose-2,6-bisphosphate 2-phosphatase activity; protein binding; protein kinase binding
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Biological Process:
carbohydrate phosphorylation; fructose 2,6-bisphosphate metabolic process; fructose metabolic process; glucose catabolic process; glycolytic process; lactate metabolic process; positive regulation of glucokinase activity; positive regulation of insulin secretion; response to glucose
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Reference #:
O60825
(UniProtKB)
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Alt. Names/Synonyms: 6-phosphofructo-2-kinase; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2; 6PF-2-K/Fru-2,6-P2ase 2; 6PF-2-K/Fru-2,6-P2ase heart-type isozyme; DKFZp781D2217; F262; Fructose-2,6-bisphosphatase; fructose-2,6-bisphosphatase, cardiac isozyme; MGC138308; MGC138310; PFK-2/FBPase-2; PFK/FBPase 2; PFKFB, cardiac; PFKFB2
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Gene Symbols: PFKFB2
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Molecular weight:
58,477 Da
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Basal Isoelectric point:
8.61
Predict pI for various phosphorylation states
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CST Pathways:
PI3K/Akt Signaling
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Warburg Effect
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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