PFKFB2 Synthesis and degradation of fructose 2,6-bisphosphate. In the C-terminal section; belongs to the phosphoglycerate mutase family. Heart. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - fructose and mannose; EC; EC; Kinase, other; Motility/polarity/chemotaxis; Phosphatase (non-protein)
Chromosomal Location of Human Ortholog: 1q32.1
Cellular Component:  cytosol; nucleoplasm; nucleus
Molecular Function:  6-phosphofructo-2-kinase activity; ATP binding; protein binding; protein kinase binding
Biological Process:  carbohydrate phosphorylation; dephosphorylation; fructose metabolic process; glucose catabolic process; glycolytic process; lactate metabolic process; positive regulation of glucokinase activity; positive regulation of glycolytic process; positive regulation of insulin secretion; response to glucose
Reference #:  O60825 (UniProtKB)
Alt. Names/Synonyms: 6-phosphofructo-2-kinase; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2; 6PF-2-K/Fru-2,6-P2ase 2; 6PF-2-K/Fru-2,6-P2ase heart-type isozyme; DKFZp781D2217; F262; Fructose-2,6-bisphosphatase; fructose-2,6-bisphosphatase, cardiac isozyme; MGC138308; MGC138310; PFK-2/FBPase-2; PFK/FBPase 2; PFKFB, cardiac; PFKFB2
Gene Symbols: PFKFB2
Molecular weight: 58,477 Da
Basal Isoelectric point: 8.61  Predict pI for various phosphorylation states
CST Pathways:  PI3K/Akt Signaling  |  Warburg Effect
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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