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TACC2
Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors. May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. Belongs to the TACC family. Strongly expressed in heart, skeletal muscle, brain, prostate, thyroid and trachea. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell cycle regulation |
| Chromosomal Location of mouse Ortholog: 7|7 F3 |
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Cellular Component:
cytoplasm; cytoskeleton; cytosol; nucleoplasm; nucleus; plasma membrane
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Molecular Function:
nuclear receptor binding; protein domain specific binding
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Biological Process:
astral microtubule organization; cell population proliferation; cerebral cortex development; interkinetic nuclear migration; microtubule cytoskeleton organization; mitotic spindle organization; neurogenesis; regulation of microtubule-based process
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Reference #:
E9Q8T1
(UniProtKB)
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Alt. Names/Synonyms: KIAA4180; mKIAA4180; Tacc2; Transforming acidic coiled-coil-containing protein 2; transforming acidic coiled-coil-containing protein 2 isoform c; transforming, acidic coiled-coil containing protein 2
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Gene Symbols: Tacc2
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Molecular weight:
305,231 Da
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Basal Isoelectric point:
4.71
Predict pI for various phosphorylation states
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