TACC2 Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors. May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. Belongs to the TACC family. Strongly expressed in heart, skeletal muscle, brain, prostate, thyroid and trachea. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 10q26.13
Cellular Component:  cytosol; microtubule organizing center; nucleoplasm; plasma membrane
Molecular Function:  nuclear hormone receptor binding
Biological Process:  mitotic spindle organization
Reference #:  O95359 (UniProtKB)
Alt. Names/Synonyms: anti zuai-1; Anti-Zuai-1; AZU-1; ECTACC; TACC2; transforming acidic coiled-coil containing protein 2; Transforming acidic coiled-coil-containing protein 2; transforming, acidic coiled-coil containing protein 2
Gene Symbols: TACC2
Molecular weight: 309,427 Da
Basal Isoelectric point: 4.71  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  Ensembl Protein