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NPM1
Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade. In complex with MYC enhances the transcription of MYC target genes. Belongs to the nucleoplasmin family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Nucleolus; Oncoprotein; RNA-binding; Translation |
| Chromosomal Location of human Ortholog: 5q35.1 |
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Cellular Component:
centrosome; cytoplasm; cytosol; granular component; large ribosomal subunit; nuclear speck; nucleolus; nucleoplasm; nucleus; protein-containing complex; protein-DNA complex; ribonucleoprotein complex; small ribosomal subunit; spindle pole centrosome
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Molecular Function:
chromatin binding; core promoter sequence-specific DNA binding; DNA-binding transcription factor binding; histone binding; molecular condensate scaffold activity; NF-kappaB binding; protein binding; protein homodimerization activity; protein kinase binding; protein kinase inhibitor activity; ribosomal large subunit binding; ribosomal small subunit binding; RNA binding; rRNA binding; Tat protein binding; transcription coactivator activity; unfolded protein binding
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Biological Process:
cell volume homeostasis; cellular response to UV; cellular senescence; centrosome cycle; chromatin remodeling; DNA repair; intracellular protein transport; negative regulation of apoptotic process; negative regulation of cell population proliferation; negative regulation of centrosome duplication; negative regulation of mRNA splicing, via spliceosome; negative regulation of protein kinase activity by regulation of protein phosphorylation; nucleocytoplasmic transport; nucleosome assembly; positive regulation of cell cycle G2/M phase transition; positive regulation of cell population proliferation; positive regulation of centrosome duplication; positive regulation of DNA-templated transcription; positive regulation of NF-kappaB transcription factor activity; positive regulation of protein kinase activity; positive regulation of protein localization to nucleolus; positive regulation of protein ubiquitination; positive regulation of transcription by RNA polymerase II; positive regulation of translation; protein localization; protein stabilization; regulation of cell growth; regulation of centriole replication; regulation of centrosome duplication; regulation of DNA damage response, signal transduction by p53 class mediator; regulation of eIF2 alpha phosphorylation by dsRNA; regulation of endodeoxyribonuclease activity; regulation of endoribonuclease activity; regulation of mRNA stability involved in cellular response to UV; ribosomal large subunit biogenesis; ribosomal large subunit export from nucleus; ribosomal small subunit biogenesis; ribosomal small subunit export from nucleus; ribosome assembly; rRNA export from nucleus; signal transduction
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Disease: Leukemia, Acute Myeloid
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Reference #:
P06748
(UniProtKB)
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Alt. Names/Synonyms: B23; MGC104254; NPM; NPM1; Nucleolar phosphoprotein B23; Nucleolar protein NO38; Nucleophosmin; nucleophosmin (nucleolar phosphoprotein B23, numatrin); nucleophosmin 1; nucleophosmin/nucleoplasmin family, member 1; Numatrin; testicular tissue protein Li 128
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Gene Symbols: NPM1
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Molecular weight:
32,575 Da
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Basal Isoelectric point:
4.64
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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