TNIP1 Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection. Ubiquitous. Strongly expressed in peripheral blood lymphocytes, spleen and skeletal muscle, and is weakly expressed in the brain. In peripheral blood mononucleocytes, isoform 4 is mainly expressed and isoform 1 and isoform 7 are almost not expressed. Expression of isoform 1 and isoform 7 increases in leukemic cells. 8 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription regulation
Chromosomal Location of Human Ortholog: 11|11 B1.3
Cellular Component:  cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function:  identical protein binding; mitogen-activated protein kinase binding; polyubiquitin modification-dependent protein binding; protein binding
Biological Process:  glycoprotein biosynthetic process; inflammatory response; leukocyte cell-cell adhesion; modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade; MyD88-dependent toll-like receptor signaling pathway; negative regulation of ERK1 and ERK2 cascade; negative regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of inflammatory response; positive regulation of protein deubiquitination; positive regulation of transcription by RNA polymerase II; regulation of inflammatory response
Reference #:  Q9WUU8 (UniProtKB)
Alt. Names/Synonyms: A20-binding inhibitor of NF-kappa B activation; A20-binding inhibitor of NF-kappa-B activation; A20-binding inhibitor of NF-kappa-B activation 1; ABIN; ABIN-1; ABIN1; AU018810; mVAN; Naf1; Nef; Nef-associated factor 1; OTTMUSP00000006672; OTTMUSP00000006674; TNFAIP3 interacting protein 1; TNFAIP3-interacting protein 1; Tnip1; VAN; Virion-associated nuclear shuttling protein
Gene Symbols: Tnip1
Molecular weight: 73,050 Da
Basal Isoelectric point: 5.77  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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TNIP1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene