PHOX2A May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype. Belongs to the paired homeobox family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 11q13.4
Cellular Component:  nuclear chromatin
Molecular Function:  DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II regulatory region sequence-specific DNA binding
Biological Process:  dopaminergic neuron differentiation; locus ceruleus development; midbrain development; noradrenergic neuron differentiation; oculomotor nerve formation; positive regulation of transcription by RNA polymerase II; regulation of respiratory gaseous exchange; somatic motor neuron differentiation; sympathetic nervous system development; trochlear nerve formation
Disease: Fibrosis Of Extraocular Muscles, Congenital, 2
Reference #:  O14813 (UniProtKB)
Alt. Names/Synonyms: aristaless homeobox homolog; Aristaless homeobox protein homolog; ARIX; arix homeodomain protein; ARIX1 homeodomain protein; CFEOM2; FEOM2; MGC52227; NCAM2; paired like homeobox 2A; Paired mesoderm homeobox protein 2A; Paired-like homeobox 2A; PHOX2A; PHX2A; PMX2A
Gene Symbols: PHOX2A
Molecular weight: 29,653 Da
Basal Isoelectric point: 8.98  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene