UGT2B7 UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Its unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in regulating the level and activity of these potent and active estrogen metabolites. Is also active with androsterone, hyodeoxycholic acid and tetrachlorocatechol (in vitro). Belongs to the UDP-glycosyltransferase family. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - pentose and glucuronate interconversions; Carbohydrate Metabolism - starch and sucrose; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Cofactor and Vitamin Metabolism - retinol; EC 2.4.1.17; Lipid Metabolism - androgen and estrogen; Membrane protein, integral; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - drug metabolism - other enzymes; Xenobiotic Metabolism - metabolism by cytochrome P450
Chromosomal Location of human Ortholog: 4q13.2
Cellular Component:  endoplasmic reticulum membrane; integral component of membrane; membrane
Molecular Function:  glucuronosyltransferase activity
Biological Process:  androgen metabolic process; cellular glucuronidation; lipid metabolic process
Reference #:  P16662 (UniProtKB)
Alt. Names/Synonyms: 3,4-catechol estrogen specific; 3,4-catechol estrogen-specific UDPGT; UD2B7; UDP glucuronosyltransferase 2 family, polypeptide B7; UDP glucuronosyltransferase 2B7; UDP glucuronosyltransferase family 2 member B7; UDP-glucuronosyltransferase 2B7; UDP-glucuronosyltransferase 2B9; UDP-glucuronyltransferase, family 2, beta-7; UDPGT 2B7; UDPGT 2B9; UDPGT2B7; UDPGTh-2; UDPGTH2; UGT2B7; UGT2B9; UGTB2B9
Gene Symbols: UGT2B7
Molecular weight: 60,721 Da
Basal Isoelectric point: 8.54  Predict pI for various phosphorylation states
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UGT2B7

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB