GALNT3
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward HIV envelope glycoprotein gp120, EA2, Muc2 and Muc5. Probably glycosylates fibronectin in vivo. Glycosylates FGF23. Plays a central role in phosphate homeostasis. Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily. Expressed in organs that contain secretory epithelial glands. Highly expressed in pancreas, skin, kidney and testis. Weakly expressed in prostate, ovary, intestine and colon. Also expressed in placenta and lung and fetal lung and fetal kidney. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: EC 2.4.1.41; Glycan Metabolism - O-glycan biosynthesis; Membrane protein, integral; Transferase |
Chromosomal Location of human Ortholog: 2q24.3 |
Cellular Component:
Golgi apparatus; Golgi cisterna membrane; Golgi membrane; membrane; perinuclear region of cytoplasm
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Molecular Function:
calcium ion binding; carbohydrate binding; manganese ion binding; polypeptide N-acetylgalactosaminyltransferase activity
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Biological Process:
carbohydrate metabolic process; fibroblast growth factor receptor signaling pathway; O-glycan processing; protein O-linked glycosylation; protein O-linked glycosylation via serine; protein O-linked glycosylation via threonine; spermatogenesis
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Disease: Tumoral Calcinosis, Hyperphosphatemic, Familial
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Reference #:
Q14435
(UniProtKB)
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Alt. Names/Synonyms: DKFZp686C10199; GalNAc transferase 3; GalNAc-T3; GALNT3; GALT3; HFTC; HFTC1; HHS; MGC61909; Polypeptide GalNAc transferase 3; polypeptide GalNAc-transferase T3; Polypeptide N-acetylgalactosaminyltransferase 3; pp-GaNTase 3; Protein-UDP acetylgalactosaminyltransferase 3; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
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Gene Symbols: GALNT3
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Molecular weight:
72,610 Da
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Basal Isoelectric point:
8.2
Predict pI for various phosphorylation states
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