TRPC4AP
Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Adaptor/scaffold |
Chromosomal Location of human Ortholog: 20q11.22 |
Cellular Component:
Cul4-RING E3 ubiquitin ligase complex; Cul4A-RING E3 ubiquitin ligase complex; perinuclear region of cytoplasm; plasma membrane
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Molecular Function:
calcium channel activity; phosphatase binding; protein binding; ubiquitin ligase-substrate adaptor activity
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Biological Process:
calcium ion transmembrane transport; hair follicle maturation; protein ubiquitination; ubiquitin-dependent protein catabolic process; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
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Reference #:
Q8TEL6
(UniProtKB)
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Alt. Names/Synonyms: C20orf188; PPP1R158; protein phosphatase 1, regulatory subunit 158; Protein TAP1; Protein TRUSS; short transient receptor potential channel 4 associated protein; Short transient receptor potential channel 4-associated protein; TNF-receptor ubiquitous scaffolding/signaling protein; TP4AP; transient receptor potential cation channel subfamily C member 4 associated protein; transient receptor potential cation channel, subfamily C, member 4 associated protein; Trp4-associated protein; Trpc4-associated protein; TRPC4AP; TRRP4AP; TRUSS; tumor necrosis factor receptor-associated ubiquitous scaffolding and signaling protein
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Gene Symbols: TRPC4AP
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Molecular weight:
90,852 Da
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Basal Isoelectric point:
7.54
Predict pI for various phosphorylation states
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