GPAA1 Essential for GPI-anchoring of precursor proteins but not for GPI synthesis. Acts before or during formation of the carbonyl intermediate. Ubiquitously expressed in fetal and adult tissues. Expressed at higher levels in fetal tissues than adult tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Endoplasmic reticulum; Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of mouse Ortholog: 15|15 D3
Cellular Component:  centrosome; cytosol; endoplasmic reticulum; GPI-anchor transamidase complex; membrane; mitochondrion; plasma membrane
Molecular Function:  GPI anchor binding; GPI-anchor transamidase activity
Biological Process:  attachment of GPI anchor to protein; GPI anchor biosynthetic process; protein-containing complex assembly
Reference #:  Q9WTK3 (UniProtKB)
Alt. Names/Synonyms: C80044; Gaa1; GAA1 protein homolog; Glycosylphosphatidylinositol anchor attachment 1 protein; Gpaa1; GPI anchor attachment protein 1; mGA; mGAA1
Gene Symbols: Gpaa1
Molecular weight: 67,949 Da
Basal Isoelectric point: 8.61  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene