GPAA1 Essential for GPI-anchoring of precursor proteins but not for GPI synthesis. Acts before or during formation of the carbonyl intermediate. Ubiquitously expressed in fetal and adult tissues. Expressed at higher levels in fetal tissues than adult tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Endoplasmic reticulum; Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of human Ortholog: 8q24.3
Cellular Component:  centrosome; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; GPI-anchor transamidase complex; mitochondrion
Molecular Function:  GPI anchor binding; GPI-anchor transamidase activity; protein binding; tubulin binding
Biological Process:  attachment of GPI anchor to protein; protein retention in ER lumen; protein-containing complex assembly
Disease: Glycosylphosphatidylinositol Biosynthesis Defect 15
Reference #:  O43292 (UniProtKB)
Alt. Names/Synonyms: anchor attachment protein 1 (Gaa1p, yeast) homolog; GAA1; GAA1 protein homolog; glycophosphatidylinositol anchor attachment 1; glycosylphosphatidylinositol anchor attachment 1; Glycosylphosphatidylinositol anchor attachment 1 protein; glycosylphosphatidylinositol anchor attachment protein 1 homolog; glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast); GPAA1; GPAA1P anchor attachment protein 1 homolog; GPI anchor attachment protein 1; GPI transamidase subunit; GPIBD15; hGAA1
Gene Symbols: GPAA1
Molecular weight: 67,623 Da
Basal Isoelectric point: 8.15  Predict pI for various phosphorylation states
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GPAA1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene