NUDT7 Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3',5'-ADP and the corresponding 4'-phosphopantetheine derivative as products. CoA into 3',5'-ADP and 4'- phosphopantetheine. Has no activity toward NDP-sugars, CDP- alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand. Belongs to the Nudix hydrolase family. PCD1 subfamily. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.1.-; Hydrolase
Chromosomal Location of Human Ortholog: 8|8 E1
Cellular Component:  peroxisome
Molecular Function:  acetyl-CoA hydrolase activity; hydrolase activity; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; m7G(5')pppN diphosphatase activity; magnesium ion binding; manganese ion binding; metal ion binding; receptor binding; RNA binding; snoRNA binding
Biological Process:  acetyl-CoA catabolic process; brown fat cell differentiation; coenzyme A catabolic process; nucleoside diphosphate metabolic process
Reference #:  Q99P30 (UniProtKB)
Alt. Names/Synonyms: 1300007B24Rik; 2210404C19Rik; coenzyme A diphosphatase; Nucleoside diphosphate-linked moiety X motif 7; nudix (nucleoside diphosphate linked moiety X)-type motif 7; Nudix motif 7; Nudt7; Peroxisomal coenzyme A diphosphatase NUDT7
Gene Symbols: Nudt7
Molecular weight: 26,857 Da
Basal Isoelectric point: 5.9  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene