RHOT2 Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution. Belongs to the mitochondrial Rho GTPase family. Ubiquitously expressed. Highly expressed in heart, liver, skeletal muscle, kidney and pancreas. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.5.-; G protein; G protein, monomeric; G protein, monomeric, Rho; Hydrolase; Membrane protein, integral; Mitochondrial
Chromosomal Location of human Ortholog: 16p13.3
Cellular Component:  cytosol; integral component of mitochondrial outer membrane; plasma membrane
Molecular Function:  calcium ion binding; protein binding
Biological Process:  cellular homeostasis; mitochondrial outer membrane permeabilization; mitochondrion transport along microtubule; regulation of small GTPase mediated signal transduction
Reference #:  Q8IXI1 (UniProtKB)
Alt. Names/Synonyms: ARHT2; C16orf39; hMiro-2; MIRO-2; MIRO2; mitochondrial Rho (MIRO) GTPase 2; mitochondrial Rho 2; Mitochondrial Rho GTPase 2; ras homolog family member T2; Ras homolog gene family member T2; ras homolog gene family, member T2; RASL; RHOT2
Gene Symbols: RHOT2
Molecular weight: 68,118 Da
Basal Isoelectric point: 5.55  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Microtubule Dynamics
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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RHOT2

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB