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PTGR3
Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficienty towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation. Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 1.-.-.-; Oxidoreductase |
| Chromosomal Location of mouse Ortholog: 18|18 E4 |
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Cellular Component:
peroxisome
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Molecular Function:
13-prostaglandin reductase activity; 15-oxoprostaglandin 13-oxidase activity; oxidoreductase activity; zinc ion binding
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Biological Process:
lipid metabolic process; negative regulation of fat cell differentiation
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Reference #:
Q8BGC4
(UniProtKB)
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Alt. Names/Synonyms: 15-oxoprostaglandin 13-reductase; C530046K17Rik; MGC32469; Prostaglandin reductase-3; PTGR-3; PTGR3; Pth; Pthr3; Zadh2; zinc binding alcohol dehydrogenase, domain containing 2; Zinc-binding alcohol dehydrogenase domain-containing protein 2
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Gene Symbols: Ptgr3
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Molecular weight:
40,529 Da
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Basal Isoelectric point:
7.01
Predict pI for various phosphorylation states
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