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EGR1
Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary. Regulates the amplitude of the expression rhythms of clock genes: ARNTL/BMAL1, PER2 and NR1D1 in the liver via the activation of PER1 (clock repressor) transcription. Regulates the rhythmic expression of core-clock gene ARNTL/BMAL1 in the suprachiasmatic nucleus (SCN). Belongs to the EGR C2H2-type zinc-finger protein family. Detected in neutrophils (at protein level). Note: This description may include information from UniProtKB.
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| Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor |
| Chromosomal Location of human Ortholog: 5q31.2 |
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Cellular Component:
chromatin; cytoplasm; nucleoplasm; nucleus
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Molecular Function:
DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; double-stranded methylated DNA binding; hemi-methylated DNA-binding; histone acetyltransferase binding; promoter-specific chromatin binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding; zinc ion binding
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Biological Process:
BMP signaling pathway; cellular response to gamma radiation; cellular response to heparin; cellular response to interleukin-8; cellular response to mycophenolic acid; circadian regulation of gene expression; circadian temperature homeostasis; estrous cycle; glomerular mesangial cell proliferation; interleukin-1-mediated signaling pathway; locomotor rhythm; negative regulation of canonical Wnt signaling pathway; negative regulation of transcription by RNA polymerase II; positive regulation of chemokine production; positive regulation of DNA-templated transcription; positive regulation of gene expression; positive regulation of glomerular metanephric mesangial cell proliferation; positive regulation of hormone biosynthetic process; positive regulation of interleukin-1 beta production; positive regulation of miRNA transcription; positive regulation of post-translational protein modification; positive regulation of tau-protein kinase activity; positive regulation of transcription by RNA polymerase II; regulation of neuron apoptotic process; regulation of progesterone biosynthetic process; regulation of protein sumoylation; regulation of transcription by RNA polymerase II; regulation of transcription from RNA polymerase II promoter in response to hypoxia; response to glucose; response to hypoxia; response to insulin; response to ischemia; skeletal muscle cell differentiation; T cell differentiation
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Reference #:
P18146
(UniProtKB)
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Alt. Names/Synonyms: AT225; early growth response 1; Early growth response protein 1; EGR-1; EGR1; G0S30; KROX-24; KROX24; Nerve growth factor-induced protein A; NGFI-A; TIS8; Transcription factor ETR103; Transcription factor Zif268; ZIF-268; Zinc finger protein 225; Zinc finger protein Krox-24; ZNF225
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Gene Symbols: EGR1
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Molecular weight:
57,507 Da
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Basal Isoelectric point:
8.51
Predict pI for various phosphorylation states
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CST Pathways:
B Cell Receptor Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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