PDE6C
As cone-specific cGMP phosphodiesterase, it plays an essential role in light detection and cone phototransduction by rapidly decreasing intracellular levels of cGMP. Belongs to the cyclic nucleotide phosphodiesterase family. Note: This description may include information from UniProtKB.
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Protein type: EC 3.1.4.35; Phosphodiesterase |
Chromosomal Location of human Ortholog: 10q23.33 |
Cellular Component:
plasma membrane
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Molecular Function:
3',5'-cyclic-GMP phosphodiesterase activity; 3',5'-cyclic-nucleotide phosphodiesterase activity; cGMP binding; metal ion binding
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Biological Process:
phototransduction, visible light; retinal cone cell development; signal transduction; visual perception
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Disease: Cone Dystrophy 4
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Reference #:
P51160
(UniProtKB)
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Alt. Names/Synonyms: ACHM5; cGMP phosphodiesterase 6C; COD4; Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; PDE6C; PDEA2; phosphodiesterase 6C; phosphodiesterase 6C, cGMP-specific, cone, alpha prime
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Gene Symbols: PDE6C
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Molecular weight:
99,147 Da
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Basal Isoelectric point:
5.5
Predict pI for various phosphorylation states
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