PDE6C As cone-specific cGMP phosphodiesterase, it plays an essential role in light detection and cone phototransduction by rapidly decreasing intracellular levels of cGMP. Belongs to the cyclic nucleotide phosphodiesterase family. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.4.35; Phosphodiesterase
Chromosomal Location of human Ortholog: 10q23.33
Cellular Component:  plasma membrane
Molecular Function:  3',5'-cyclic-GMP phosphodiesterase activity; cGMP binding; metal ion binding
Biological Process:  phototransduction, visible light; retinal cone cell development
Disease: Cone Dystrophy 4
Reference #:  P51160 (UniProtKB)
Alt. Names/Synonyms: ACHM5; cGMP phosphodiesterase 6C; COD4; Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; PDE6C; PDEA2; phosphodiesterase 6C; phosphodiesterase 6C, cGMP-specific, cone, alpha prime
Gene Symbols: PDE6C
Molecular weight: 99,147 Da
Basal Isoelectric point: 5.5  Predict pI for various phosphorylation states
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PDE6C

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene