ABCC4
May be an organic anion pump relevant to cellular detoxification. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. Widely expressed, with particularly high levels in prostate, but is barely detectable in liver. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family |
Chromosomal Location of human Ortholog: 13q32.1 |
Cellular Component:
apical plasma membrane; basolateral plasma membrane; external side of apical plasma membrane; Golgi apparatus; membrane; nucleolus; plasma membrane; platelet dense granule membrane
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Molecular Function:
15-hydroxyprostaglandin dehydrogenase (NAD+) activity; ABC-type bile acid transporter activity; ABC-type glutathione S-conjugate transporter activity; ABC-type transporter activity; ABC-type xenobiotic transporter activity; ATP binding; ATP hydrolysis activity; ATPase-coupled inorganic anion transmembrane transporter activity; ATPase-coupled transmembrane transporter activity; efflux transmembrane transporter activity; glutathione transmembrane transporter activity; guanine nucleotide transmembrane transporter activity; prostaglandin transmembrane transporter activity; protein binding; purine nucleotide transmembrane transporter activity; urate transmembrane transporter activity; xenobiotic transmembrane transporter activity
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Biological Process:
bile acid and bile salt transport; cAMP transport; cilium assembly; export across plasma membrane; glutathione transmembrane transport; guanine nucleotide transmembrane transport; leukotriene transport; monoatomic anion transmembrane transport; platelet degranulation; prostaglandin secretion; prostaglandin transport; transmembrane transport; transport across blood-brain barrier; urate transport; xenobiotic metabolic process; xenobiotic transmembrane transport
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Reference #:
O15439
(UniProtKB)
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Alt. Names/Synonyms: ABCC4; ATP binding cassette subfamily C member 4; ATP-binding cassette sub-family C member 4; ATP-binding cassette, sub-family C (CFTR/MRP), member 4; bA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4); canalicular multispecific organic anion transporter (ABC superfamily); EST170205; MOAT-B; MOATB; MRP/cMOAT-related ABC transporter; MRP4; Multi-specific organic anion transporter B; Multidrug resistance-associated protein 4; multispecific organic anion transporter B
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Gene Symbols: ABCC4
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Molecular weight:
149,527 Da
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Basal Isoelectric point:
8.41
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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