CRAT
Catalyzes the reversible transfer of acyl groups from carnitine to coenzyme A (CoA) and regulates the acyl-CoA/CoA ratio. Also plays a crucial role in the transport of fatty acids for beta-oxidation. May be specific for short chain fatty acids. Belongs to the carnitine/choline acetyltransferase family. Mostly in skeletal muscle, less in heart, liver and pancreas, only weakly detectable in brain, placenta, lung and kidney. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Acetyltransferase; EC 2.3.1.7; Mitochondrial |
Chromosomal Location of human Ortholog: 9q34.11 |
Cellular Component:
cytosol; endoplasmic reticulum; mitochondrial inner membrane; mitochondrion; peroxisomal matrix; peroxisome
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Molecular Function:
acyl-CoA oxidase activity; carnitine O-acetyltransferase activity; carnitine O-octanoyltransferase activity
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Biological Process:
carnitine metabolic process, CoA-linked; fatty acid beta-oxidation using acyl-CoA oxidase; medium-chain fatty acid metabolic process; short-chain fatty acid metabolic process
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Disease: Neurodegeneration With Brain Iron Accumulation 8
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Reference #:
P43155
(UniProtKB)
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Alt. Names/Synonyms: CACP; Carnitine acetylase; Carnitine acetyltransferase; Carnitine O-acetyltransferase; CAT; CAT1; CRAT; NBIA8
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Gene Symbols: CRAT
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Molecular weight:
70,858 Da
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Basal Isoelectric point:
8.63
Predict pI for various phosphorylation states
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