Ephx1 Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. May play a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids. Belongs to the peptidase S33 family. Found in liver. Note: This description may include information from UniProtKB.
Protein type: EC; Hydrolase; Membrane protein, integral; Xenobiotic Metabolism - metabolism by cytochrome P450
Chromosomal Location of human Ortholog: 1q42.12
Cellular Component:  endoplasmic reticulum membrane
Molecular Function:  cis-stilbene-oxide hydrolase activity; epoxide hydrolase activity; protein binding
Biological Process:  arachidonic acid metabolic process; aromatic compound catabolic process; epoxide metabolic process; response to organic cyclic compound; response to toxic substance; xenobiotic metabolic process
Disease: Hypercholanemia, Familial
Reference #:  P07099 (UniProtKB)
Alt. Names/Synonyms: EPHX; EPHX1; EPOX; Epoxide hydratase; Epoxide hydrolase 1; epoxide hydrolase 1 microsomal; epoxide hydrolase 1, microsomal (xenobiotic); HYEP; HYL1; MEH; Microsomal epoxide hydrolase
Gene Symbols: EPHX1
Molecular weight: 52,949 Da
Basal Isoelectric point: 6.77  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene