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Ephx1
Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. May play a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids. Belongs to the peptidase S33 family. Found in liver. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.3.2.9; Hydrolase; Membrane protein, integral; Xenobiotic Metabolism - metabolism by cytochrome P450 |
| Chromosomal Location of human Ortholog: 1q42.12 |
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Cellular Component:
endoplasmic reticulum membrane
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Molecular Function:
cis-stilbene-oxide hydrolase activity; epoxide hydrolase activity; protein binding
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Biological Process:
arachidonic acid metabolic process; aromatic compound catabolic process; epoxide metabolic process; response to organic cyclic compound; response to toxic substance; xenobiotic metabolic process
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Disease: Hypercholanemia, Familial
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Reference #:
P07099
(UniProtKB)
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Alt. Names/Synonyms: EPHX; EPHX1; EPOX; Epoxide hydratase; Epoxide hydrolase 1; epoxide hydrolase 1 microsomal; epoxide hydrolase 1, microsomal (xenobiotic); HYEP; HYL1; MEH; Microsomal epoxide hydrolase
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Gene Symbols: EPHX1
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Molecular weight:
52,949 Da
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Basal Isoelectric point:
6.77
Predict pI for various phosphorylation states
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