SRSF10 Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing. Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70. Required for splicing repression in M-phase cells and after heat shock. Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing. May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator. Belongs to the splicing factor SR family. Widely expressed. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; RNA-binding
Chromosomal Location of Human Ortholog: 4|4 D3
Cellular Component:  nuclear speck; nucleoplasm; nucleus
Molecular Function:  nucleic acid binding; RNA binding; unfolded protein binding
Biological Process:  cytosolic transport; mRNA 5'-splice site recognition; mRNA cis splicing, via spliceosome; mRNA processing; mRNA splice site selection; mRNA splicing, via spliceosome; negative regulation of mRNA splicing, via spliceosome; regulation of alternative mRNA splicing, via spliceosome; regulation of mRNA splicing, via spliceosome; regulation of RNA splicing; regulation of transcription, DNA-templated; RNA splicing; RNA splicing, via transesterification reactions
Reference #:  Q9R0U0 (UniProtKB)
Alt. Names/Synonyms: FUS; FUS interacting protein (serine-arginine rich) 1; Fus-associated protein with serine-arginine repeats; FUS-interacting serine-arginine-rich protein 1; Fusip1; FUSIP2; Neural-salient serine/arginine-rich protein; Neural-specific SR protein; Nssr; NSSR1; NSSR2; OTTMUSP00000010356; OTTMUSP00000010357; RP23-161N17.2; serine and arginine-rich splicing factor 10; Serine/arginine-rich splicing factor 10; serine/arginine-rich splicing factor 13A; SF13A; Sfr; Sfrs13a; Splicing factor, arginine/serine-rich 13A; SRrp40; Srs; SRS10; SRSF10; Srsf13a; TASR; TASR1; TASR2; TLS-associated protein with Ser-Arg repeats; TLS-associated protein with SR repeats; TLS-associated serine-arginine protein; TLS-associated SR protein
Gene Symbols: Sfrs13a
Molecular weight: 31,301 Da
Basal Isoelectric point: 11.26  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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SRSF10

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene