CCNE1 Essential for the control of the cell cycle at the G1/S (start) transition. Belongs to the cyclin family. Cyclin E subfamily. Highly expressed in testis and placenta. Low levels in bronchial epithelial cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Activator; Cell cycle regulation; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 19q12
Cellular Component:  cyclin E1-CDK2 complex; cytosol; nucleoplasm; nucleus
Molecular Function:  androgen receptor binding; protein binding; transcription coactivator activity
Biological Process:  androgen receptor signaling pathway; cell division; DNA replication initiation; G1/S transition of mitotic cell cycle; negative regulation of transcription by RNA polymerase II; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of transcription, DNA-templated; protein phosphorylation; regulation of cellular protein localization; regulation of transcription involved in G1/S transition of mitotic cell cycle; telomere maintenance; Wnt signaling pathway
Reference #:  P24864 (UniProtKB)
Alt. Names/Synonyms: CCNE; CCNE1; cyclin E1; cyclin Es; cyclin Et; G1/S-specific cyclin-E1
Gene Symbols: CCNE1
Molecular weight: 47,077 Da
Basal Isoelectric point: 5.7  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CCNE1

Protein Structure Not Found.


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