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CCNB1
Essential for the control of the cell cycle at the G2/M (mitosis) transition. Belongs to the cyclin family. Cyclin AB subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Activator; Cell cycle regulation |
| Chromosomal Location of human Ortholog: 5q13.2 |
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Cellular Component:
centrosome; cyclin B1-CDK1 complex; cytoplasm; cytosol; membrane; mitochondrial matrix; nucleoplasm; nucleus; outer kinetochore; spindle pole
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Molecular Function:
cyclin-dependent protein serine/threonine kinase activator activity; cyclin-dependent protein serine/threonine kinase regulator activity; molecular adaptor activity; patched binding; protein binding; protein kinase binding; ubiquitin-like protein ligase binding
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Biological Process:
cell division; G2/M transition of mitotic cell cycle; in utero embryonic development; mitotic cell cycle phase transition; mitotic metaphase plate congression; mitotic spindle organization; positive regulation of attachment of spindle microtubules to kinetochore; positive regulation of fibroblast proliferation; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of mitochondrial ATP synthesis coupled electron transport; positive regulation of mitotic cell cycle; protein phosphorylation; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of mitotic cell cycle spindle assembly checkpoint
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Reference #:
P14635
(UniProtKB)
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Alt. Names/Synonyms: CCNB; CCNB1; cyclin B1; G2/mitotic-specific cyclin B1; G2/mitotic-specific cyclin-B1
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Gene Symbols: CCNB1
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Molecular weight:
48,337 Da
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Basal Isoelectric point:
7.09
Predict pI for various phosphorylation states
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CST Pathways:
AMPK Signaling
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G2/M DNA Damage Checkpoint
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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