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RAI14
Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. Highly expressed in placenta, muscle, kidney and testis. Moderately expressed in heart, brain, lung, liver and intestine. Isoform 2 is widely expressed and expressed in fetal and adult testes, and spermatozoa. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
| Chromosomal Location of mouse Ortholog: 15|15 A1 |
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Cellular Component:
cell junction; cytoplasm; cytoskeleton; cytosol; fibrillar center; nucleoplasm; nucleus
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Molecular Function:
actin binding
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Biological Process:
cell differentiation; spermatogenesis
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Reference #:
Q9EP71
(UniProtKB)
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Alt. Names/Synonyms: 1700008J19Rik; 1700020L11Rik; Anky; Ankycorbin; Ankyrin repeat and coiled-coil structure-containing protein; Kiaa1334; mKIAA1334; Norpeg; NORPEG-like protein; Novel retinal pigment epithelial cell protein; p125; Rai14; retinoic acid induced 14; Retinoic acid-induced protein 14
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Gene Symbols: Rai14
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Molecular weight:
108,852 Da
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Basal Isoelectric point:
5.88
Predict pI for various phosphorylation states
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