RAI14 Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. Highly expressed in placenta, muscle, kidney and testis. Moderately expressed in heart, brain, lung, liver and intestine. Isoform 2 is widely expressed and expressed in fetal and adult testes, and spermatozoa. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of mouse Ortholog: 15|15 A1
Cellular Component:  anchoring junction; cytoplasm; cytoskeleton; cytosol; fibrillar center; nucleoplasm; nucleus
Molecular Function:  actin binding
Biological Process:  cell differentiation; spermatogenesis
Reference #:  Q9EP71 (UniProtKB)
Alt. Names/Synonyms: 1700008J19Rik; 1700020L11Rik; Anky; Ankycorbin; Ankyrin repeat and coiled-coil structure-containing protein; Kiaa1334; mKIAA1334; Norpeg; NORPEG-like protein; Novel retinal pigment epithelial cell protein; p125; Rai14; retinoic acid induced 14; Retinoic acid-induced protein 14
Gene Symbols: Rai14
Molecular weight: 108,852 Da
Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein