CIITA a non-DNA binding transactivator that functions both in constitutive and inducible MHC Class II expression. Defects are a cause of bare lymphocyte syndrome type II (BLS II), a form of severe combined immunodeficiency disease (SCID) characterized by a profound defect in constitutive and interferon-gamma induced MHC II expression, an absence of cellular and humoral T-cell response to antigen challenge, hypogammaglobulinemia and impaired antibody production. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; EC; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 16p13.13
Cellular Component:  nucleoplasm; PML body
Molecular Function:  activating transcription factor binding; ATP binding; GTP binding; kinase activity; protein binding; protein C-terminus binding; protein-containing complex binding; transcription coactivator activity; transcription regulatory region DNA binding; transferase activity, transferring acyl groups
Biological Process:  immune response; interferon-gamma-mediated signaling pathway; negative regulation of collagen biosynthetic process; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; phosphorylation; positive regulation of MHC class I biosynthetic process; positive regulation of MHC class II biosynthetic process; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; response to antibiotic; response to interferon-gamma
Disease: Bare Lymphocyte Syndrome, Type Ii; Rheumatoid Arthritis
Reference #:  P33076 (UniProtKB)
Alt. Names/Synonyms: C2TA; CIITA; CIITAIV; class II transactivator; class II, major histocompatibility complex, transactivator; MHC class II transactivator; MHC class II transactivator type III; MHC2TA; NLR family, acid domain containing; NLRA; nucleotide-binding oligomerization domain, leucine rich repeat and acid domain containing
Gene Symbols: CIITA
Molecular weight: 123,514 Da
Basal Isoelectric point: 5.3  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB