CIITA Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Exhibits intrinsic GTP-stimulated acetyltransferase activity. Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro). 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; EC; Protein kinase, Ser/Thr (non-receptor); Transcription, coactivator/corepressor
Chromosomal Location of human Ortholog: 16p13.13
Cellular Component:  nucleoplasm; PML body
Molecular Function:  activating transcription factor binding; ATP binding; GTP binding; kinase activity; protein binding; protein C-terminus binding; protein-containing complex binding; transcription coactivator activity; transcription regulatory region DNA binding; transferase activity, transferring acyl groups
Biological Process:  immune response; interferon-gamma-mediated signaling pathway; negative regulation of collagen biosynthetic process; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; phosphorylation; positive regulation of MHC class I biosynthetic process; positive regulation of MHC class II biosynthetic process; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; response to antibiotic; response to interferon-gamma
Disease: Bare Lymphocyte Syndrome, Type Ii; Rheumatoid Arthritis
Reference #:  P33076 (UniProtKB)
Alt. Names/Synonyms: C2TA; CIITA; CIITAIV; class II major histocompatibility complex transactivator; class II transactivator; class II, major histocompatibility complex, transactivator; MHC class II transactivator; MHC class II transactivator type I; MHC class II transactivator type III; MHC2TA; NLR family, acid domain containing; NLRA; nucleotide-binding oligomerization domain, leucine rich repeat and acid domain containing
Gene Symbols: CIITA
Molecular weight: 123,514 Da
Basal Isoelectric point: 5.3  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB