ARFGEF2 Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Expressed in placenta, lung, heart, brain, kidney and pancreas. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, ARF
Chromosomal Location of mouse Ortholog: 2|2 H3
Cellular Component:  asymmetric synapse; axonemal microtubule; cell junction; cell projection; cytoplasm; cytoplasmic vesicle; cytoskeleton; cytosol; dendritic spine; endosome; Golgi apparatus; Golgi membrane; membrane; microtubule organizing center; recycling endosome; symmetric synapse; synapse; trans-Golgi network
Molecular Function:  ARF guanyl-nucleotide exchange factor activity; GABA receptor binding; guanyl-nucleotide exchange factor activity; myosin binding; protein kinase A regulatory subunit binding
Biological Process:  endomembrane system organization; endosome organization; exocytosis; Golgi to plasma membrane transport; intracellular signal transduction; positive regulation of tumor necrosis factor production; protein transport; receptor recycling; regulation of ARF protein signal transduction; vesicle-mediated transport
Reference #:  A2A5R2 (UniProtKB)
Alt. Names/Synonyms: ADP-ribosylation factor guanine nucleotide-exchange factor 2; ADP-ribosylation factor guanine nucleotide-exchange factor 2 (Brefeldin A-inhibited); AI463430; Arfgef2; Arfgep2; AW493672; BIG; BIG2; Brefeldin A-inhibited GEP 2; Brefeldin A-inhibited guanine nucleotide-exchange protein 2; E230011G24Rik; MCG14609; OTTMUSP00000001103
Gene Symbols: Arfgef2
Molecular weight: 202,240 Da
Basal Isoelectric point: 6.12  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene