FAM65A Downstream effector protein for Rho-type small GTPases that plays a role in cell polarity and directional migration. Acts as an adapter protein, linking active Rho proteins to STK24 and STK26 kinases, and hence positively regulates Golgi reorientation in polarized cell migration upon Rho activation. Involved in the subcellular relocation of STK26 from the Golgi to cytoplasm punctae in a Rho- and PDCD10-dependent manner upon serum stimulation. Belongs to the RIPOR family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of mouse Ortholog: 8|8 D3
Cellular Component:  cell leading edge; cytoplasm; Golgi apparatus; membrane
Molecular Function:  14-3-3 protein binding
Biological Process:  cellular response to chemokine; cellular response to starvation; establishment of Golgi localization; negative regulation of Rho guanyl-nucleotide exchange factor activity; negative regulation of Rho protein signal transduction; positive regulation of cell migration; positive regulation of intracellular protein transport; protein localization to Golgi apparatus; response to wounding; Rho protein signal transduction
Reference #:  Q68FE6 (UniProtKB)
Alt. Names/Synonyms: 2310066E14Rik; AI837433; FA65A; Fam6; Fam65a; family with sequence similarity 65, member A; Kiaa1930; MGC100216; protein FAM65A; RHO family interacting cell polarization regulator 1; Rho family-interacting cell polarization regulator 1; Ripor1; RIPR1
Gene Symbols: Ripor1
Molecular weight: 132,352 Da
Basal Isoelectric point: 5.59  Predict pI for various phosphorylation states
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FAM65A

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein