RGS12 Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Isoform 5: Behaves as a cell cycle-dependent transcriptional repressor, promoting inhibition of S-phase DNA synthesis. Isoform 3 is brain specific. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, RGS
Chromosomal Location of mouse Ortholog: 5 B2|5 17.96 cM
Cellular Component:  apical dendrite; cell junction; cell projection; cytoplasm; cytosol; dendrite; neuronal cell body; nucleolus; nucleus; plasma membrane; protein-containing complex
Molecular Function:  G-protein alpha-subunit binding; GTPase activator activity; GTPase regulator activity; protein binding
Biological Process:  signal transduction; termination of G protein-coupled receptor signaling pathway
Reference #:  Q8CGE9 (UniProtKB)
Alt. Names/Synonyms: 1200016K18Rik; 4632412M04Rik; AI481290; E130309H11; OTTMUSP00000026922; Regulator of G-protein signaling 12; regulator of G-protein signalling 12; Rgs12
Gene Symbols: Rgs12
Molecular weight: 149,637 Da
Basal Isoelectric point: 7.54  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene