GUF1 Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.5.-; Mitochondrial
Chromosomal Location of mouse Ortholog: 5|5 C3.1
Cellular Component:  membrane; mitochondrial inner membrane; mitochondrion
Molecular Function:  GTP binding; GTPase activity; hydrolase activity; nucleotide binding
Biological Process:  translation
Reference #:  Q8C3X4 (UniProtKB)
Alt. Names/Synonyms: 4631409J12; AA407526; EF-4; Elongation factor 4 homolog; GTP-binding protein GUF1 homolog; GTPase Guf1; Guf1; GUF1 GTPase homolog; GUF1 GTPase homolog (S. cerevisiae); GUF1 homolog, GTPase; Ribosomal back-translocase; Translation factor Guf1, mitochondrial
Gene Symbols: Guf1
Molecular weight: 72,463 Da
Basal Isoelectric point: 8.87  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene