|
ACC2
Catalyzes the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in inhibition of fatty acid and glucose oxidation and enhancement of fat storage. May play a role in regulation of mitochondrial fatty acid oxidation through malonyl-CoA-dependent inhibition of carnitine palmitoyltransferase 1. Widely expressed with highest levels in heart, skeletal muscle, liver, adipose tissue, mammary gland, adrenal gland and colon (PubMed:9099716). Isoform 3 is expressed in skeletal muscle, adipose tissue and liver (at protein level) (PubMed:19190759). Isoform 3 is detected at high levels in adipose tissue with lower levels in heart, liver, skeletal muscle and testis (PubMed:19190759). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 6.3.4.14; EC 6.4.1.2; Ligase; Lipid Metabolism - fatty acid biosynthesis; Mitochondrial |
| Chromosomal Location of mouse Ortholog: 5|5 F |
|
Cellular Component:
mitochondrion; nucleus
|
|
Molecular Function:
acetyl-CoA carboxylase activity; ATP binding; biotin binding; catalytic activity; identical protein binding; ligase activity; metal ion binding; nucleotide binding
|
|
Biological Process:
acetyl-CoA metabolic process; energy homeostasis; fatty acid biosynthetic process; fatty acid metabolic process; lipid metabolic process; malonyl-CoA biosynthetic process; metabolic process; negative regulation of catalytic activity; negative regulation of fatty acid beta-oxidation; negative regulation of fatty acid oxidation; negative regulation of gene expression; negative regulation of lipid catabolic process; positive regulation of heart growth; positive regulation of lipid storage; protein homotetramerization; regulation of glucose metabolic process; response to nutrient levels; response to organic cyclic compound
|
|
Reference #:
E9Q4Z2
(UniProtKB)
|
|
Alt. Names/Synonyms: Acacb; Acc; ACC-beta; Acc2; Accb; Acetyl-CoA carboxylase 2; acetyl-Coenzyme A carboxylase beta; AI597064; AW743042; OTTMUSP00000015299
|
|
Gene Symbols: Acacb
|
|
Molecular weight:
275,750 Da
|
|
Basal Isoelectric point:
5.91
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
