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MGC4172
Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta-hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones. Belongs to the short-chain dehydrogenases/reductases (SDR) family. Isoform 1: Ubiquitously expressed, with highest levels in testis, small intestine, colon, kidney, brain and heart. Isoform 3: Expressed in brain, heart and skeletal muscle. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 1.-.-.-; Oxidoreductase; Secreted; Secreted, signal peptide |
| Chromosomal Location of Human Ortholog: 11|11 C |
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Cellular Component:
extracellular region
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Molecular Function:
17-beta-hydroxysteroid dehydrogenase (NADP+) activity; 17-beta-ketosteroid reductase activity; 3-keto sterol reductase activity; estradiol 17-beta-dehydrogenase activity; nucleotide binding; oxidoreductase activity
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Biological Process:
lipid metabolic process; oxidation-reduction process; steroid biosynthetic process; steroid metabolic process
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Reference #:
Q3U0B3
(UniProtKB)
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Alt. Names/Synonyms: 17-beta-hydroxysteroid dehydrogenase; 3-beta-hydroxysteroid 3-dehydrogenase; dehydrogenase/reductase (SDR family) member 11; Dehydrogenase/reductase SDR family member 11; DHR11; Dhrs11; Estradiol 17-beta-dehydrogenase; MGC18716; MGC4172; OTTMUSP00000000930; Sdr24c1; short-chain dehydrogenase/reductase; Short-chain dehydrogenase/reductase family 24C member 1
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Gene Symbols: Dhrs11
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Molecular weight:
28,274 Da
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Basal Isoelectric point:
5.91
Predict pI for various phosphorylation states
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