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kalirin
Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Isoform 2 is brain specific. Highly expressed in cerebral cortex, putamen, amygdala, hippocampus and caudate nucleus. Weakly expressed in brain stem and cerebellum. Isoform 4 is expressed in skeletal muscle. 6 alternative splicing and alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: CAMK group; EC 2.7.11.1; GEF; GEF, Rac/Rho; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Trio family |
| Chromosomal Location of mouse Ortholog: 16|16 B3 |
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Cellular Component:
cytoplasm; cytoskeleton; cytosol; extrinsic component of membrane; glutamatergic synapse; neuronal cell body; nucleoplasm; perinuclear region of cytoplasm; postsynaptic density; presynapse
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Molecular Function:
ATP binding; enzyme binding; guanyl-nucleotide exchange factor activity; kinase activity; metal ion binding; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
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Biological Process:
adult locomotory behavior; axon guidance; axonogenesis; habituation; intracellular signal transduction; lactation; maternal behavior; maternal process involved in parturition; memory; modification of postsynaptic actin cytoskeleton; negative regulation of growth hormone secretion; nervous system development; neuromuscular junction development; neurotransmitter receptor localization to postsynaptic specialization membrane; NMDA selective glutamate receptor signaling pathway; phosphorylation; positive regulation of dendritic spine morphogenesis; positive regulation of GTPase activity; protein phosphorylation; regulation of dendrite development; regulation of modification of postsynaptic actin cytoskeleton; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane; social behavior
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Reference #:
A2CG49
(UniProtKB)
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Alt. Names/Synonyms: 2210407G14Rik; AV235988; DUET; E530005C20Rik; Gm539; Hapip; huntingtin-associated protein interacting protein (duo); Kalirin; kalirin, RhoGEF kinase; Kalrn; OTTMUSP00000019357; OTTMUSP00000019360; Protein Duo; serine/threonine kinase with Dbl- and pleckstrin homology domain; serine/threonine kinase with Dbl- and pleckstrin homology domains; Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain; TRAD
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Gene Symbols: Kalrn
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Molecular weight:
337,000 Da
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Basal Isoelectric point:
5.72
Predict pI for various phosphorylation states
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