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RMI1
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability. Belongs to the RMI1 family. Note: This description may include information from UniProtKB.
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| Protein type: DNA repair, damage |
| Chromosomal Location of mouse Ortholog: 13|13 B1 |
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Cellular Component:
nuclear body; nucleoplasm; nucleus; RecQ family helicase-topoisomerase III complex
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Molecular Function:
nucleotide binding
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Biological Process:
DNA replication; double-strand break repair via homologous recombination; glucose homeostasis; multicellular organism growth; reduction of food intake in response to dietary excess; resolution of meiotic recombination intermediates; resolution of recombination intermediates; response to dietary excess; response to glucose
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Reference #:
Q9D4G9
(UniProtKB)
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Alt. Names/Synonyms: 4932432N11Rik; C79893; RecQ mediated genome instability 1; RecQ-mediated genome instability protein 1; Rmi1; RMI1, RecQ mediated genome instability 1, homolog; RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae)
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Gene Symbols: Rmi1
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Molecular weight:
68,465 Da
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Basal Isoelectric point:
5.25
Predict pI for various phosphorylation states
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