RARB Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. The RXRA/RARB heterodimer can act as a repressor on the DR1 element and as an activator on the DR5 element. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function. Belongs to the nuclear hormone receptor family. NR1 subfamily. Expressed in aortic endothelial cells (at protein level). 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Nuclear receptor; Oncoprotein
Chromosomal Location of mouse Ortholog: 14 A2|14 7.08 cM
Cellular Component:  nucleoplasm; nucleus; RNA polymerase II transcription factor complex
Molecular Function:  DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; drug binding; metal ion binding; nuclear receptor activity; nuclear receptor transcription coactivator activity; protein-containing complex binding; retinoid X receptor binding; RNA polymerase II regulatory region sequence-specific DNA binding; sequence-specific DNA binding; signaling receptor activity; steroid hormone receptor activity; transcription factor binding; transcription regulatory region sequence-specific DNA binding; zinc ion binding
Biological Process:  bone development; bone morphogenesis; cell differentiation; cellular response to retinoic acid; embryonic digestive tract development; embryonic eye morphogenesis; embryonic hindlimb morphogenesis; epithelium development; gland development; glandular epithelial cell development; growth plate cartilage development; hormone-mediated signaling pathway; liver development; multicellular organism development; multicellular organism growth; negative regulation of apoptotic process; negative regulation of cartilage development; negative regulation of cell proliferation; negative regulation of chondrocyte differentiation; negative regulation of transcription by RNA polymerase II; neurogenesis; outflow tract septum morphogenesis; positive regulation of apoptotic process; positive regulation of cell proliferation; positive regulation of neuron differentiation; positive regulation of programmed cell death; positive regulation of transcription by RNA polymerase II; regulation of myelination; regulation of transcription, DNA-templated; response to lipid; response to retinoic acid; retina development in camera-type eye; retinal pigment epithelium development; retinoic acid receptor signaling pathway; striatum development; ureteric bud development; ventricular cardiac muscle cell differentiation
Reference #:  P22605 (UniProtKB)
Alt. Names/Synonyms: A830025K23; Hap; Nr1b2; Nuclear receptor subfamily 1 group B member 2; RAR beta 2; RAR-beta; Rarb; RARbeta1/beta3; RARbeta2; Retinoic acid receptor beta; retinoic acid receptor beta 1/ beta 3; retinoic acid receptor, beta
Gene Symbols: Rarb
Molecular weight: 53,331 Da
Basal Isoelectric point: 8.52  Predict pI for various phosphorylation states
CST Pathways:  Wnt/ß-Catenin Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA