C/EBP-beta a bZIP transcription factor which can form homodimers or heterodimers with the related proteins CEBP-alpha, -delta and -gamma. Involved in immune and inflammatory responses. Specifically binds to regulatory regions of genes encoding IL-6, other cytokines and several acute-phase proteins. There are two forms of C/EBPbeta, the 38kDa liver activating protein (LAP) and the 20kDa liver inhibitory protein (LIP) which may be products of alternative translation. LAP is a transcriptional activator while LIP may inhibit C/EBPbeta transcriptional activity. Phosphorylated and activated by ERK1/2. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Motility/polarity/chemotaxis; Transcription factor
Chromosomal Location of Human Ortholog: 20q13.13
Cellular Component:  CHOP-C/EBP complex; condensed chromosome, centromeric region; cytoplasm; nuclear chromatin; nuclear matrix; nucleoplasm; nucleus
Molecular Function:  chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; glucocorticoid receptor binding; histone acetyltransferase binding; histone deacetylase binding; kinase binding; protein binding; protein heterodimerization activity; protein homodimerization activity; RNA polymerase II core promoter sequence-specific DNA binding; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II regulatory region sequence-specific DNA binding; ubiquitin-like protein ligase binding
Biological Process:  acute-phase response; brown fat cell differentiation; cellular response to amino acid stimulus; cellular response to interleukin-1; cellular response to lipopolysaccharide; cellular response to organic cyclic compound; defense response to bacterium; embryonic placenta development; hepatocyte proliferation; immune response; inflammatory response; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; liver regeneration; mammary gland epithelial cell differentiation; mammary gland epithelial cell proliferation; memory; negative regulation of neuron apoptotic process; negative regulation of T cell proliferation; negative regulation of transcription by RNA polymerase II; neuron differentiation; ovarian follicle development; positive regulation of biomineral tissue development; positive regulation of cold-induced thermogenesis; positive regulation of fat cell differentiation; positive regulation of inflammatory response; positive regulation of interleukin-4 production; positive regulation of osteoblast differentiation; positive regulation of sodium-dependent phosphate transport; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; positive regulation of transcription, DNA-templated; regulation of dendritic cell differentiation; regulation of interleukin-6 biosynthetic process; regulation of odontoblast differentiation; regulation of osteoclast differentiation; regulation of transcription involved in cell fate commitment; regulation of transcription, DNA-templated; response to endoplasmic reticulum stress; transcription by RNA polymerase II
Reference #:  P17676 (UniProtKB)
Alt. Names/Synonyms: C/EBP beta; C/EBP-beta; CCAAT/enhancer binding protein (C/EBP), beta; CCAAT/enhancer-binding protein beta; CEBPB; CRP2; IL6DBP; interleukin 6-dependent DNA-binding protein; LAP; Liver activator protein; liver-enriched transcriptional activator protein; MGC32080; NF-IL6; Nuclear factor NF-IL6; nuclear factor of interleukin 6; TCF-5; TCF5; Transcription factor 5
Gene Symbols: CEBPB
Molecular weight: 36,106 Da
Basal Isoelectric point: 8.55  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Growth And Differentiation Control by MAPKs  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene