MARVELD2 Plays a role in the formation of tricellular tight junctions and of epithelial barriers. Required for normal hearing via its role in the separation of the endolymphatic and perilymphatic spaces of the organ of Corti in the inner ear, and for normal survival of hair cells in the organ of Corti. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of mouse Ortholog: 13|13 D1
Cellular Component:  apical plasma membrane; basolateral plasma membrane; bicellular tight junction; cell junction; cytoplasm; cytoplasmic vesicle; membrane; paranodal junction; plasma membrane; Schmidt-Lanterman incisure; tight junction; tricellular tight junction
Molecular Function:  protein binding
Biological Process:  bicellular tight junction assembly; cell-cell junction organization; establishment of endothelial barrier; sensory perception of sound
Reference #:  Q3UZP0 (UniProtKB)
Alt. Names/Synonyms: BC003296; MALD2; MARVD2; MARVEL (membrane-associating) domain containing 2; MARVEL domain-containing protein 2; Marveld2; MGC55067; Mrvl; Mrvldc2; Tri; Tric; Trica; Tricb; Tricc; Tricellulin
Gene Symbols: Marveld2
Molecular weight: 63,662 Da
Basal Isoelectric point: 6.95  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene