HDAC4 Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1. Belongs to the histone deacetylase family. HD type 2 subfamily. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Deacetylase; EC; Hydrolase; Nuclear receptor co-regulator
Chromosomal Location of mouse Ortholog: 1|1 D
Cellular Component:  A band; actomyosin; cytoplasm; cytosol; histone deacetylase complex; neuromuscular junction; nucleoplasm; nucleus; protein-containing complex; sarcomere; transcriptional repressor complex; Z disc
Molecular Function:  activating transcription factor binding; chromatin binding; DNA binding; histone deacetylase activity; histone deacetylase binding; hydrolase activity; identical protein binding; metal ion binding; NAD-dependent histone deacetylase activity (H3-K14 specific); potassium ion binding; promoter-specific chromatin binding; protein binding; protein deacetylase activity; protein kinase binding; repressing transcription factor binding; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II transcription factor binding; SUMO transferase activity; transcription corepressor activity; transcription factor binding; zinc ion binding
Biological Process:  chromatin organization; chromatin remodeling; histone deacetylation; histone H3 deacetylation; histone H4 deacetylation; negative regulation of cell proliferation; negative regulation of DNA-binding transcription factor activity; negative regulation of glycolytic process; negative regulation of myotube differentiation; negative regulation of osteoblast differentiation; negative regulation of pri-miRNA transcription by RNA polymerase II; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; osteoblast development; peptidyl-lysine deacetylation; positive regulation of cell proliferation; positive regulation of DNA-binding transcription factor activity; positive regulation of lamellipodium assembly; positive regulation of male mating behavior; positive regulation of neuron apoptotic process; positive regulation of protein sumoylation; positive regulation of reactive oxygen species biosynthetic process; positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; protein deacetylation; regulation of cardiac muscle contraction by calcium ion signaling; regulation of gene expression, epigenetic; regulation of protein binding; regulation of skeletal muscle fiber development; regulation of striated muscle cell differentiation; response to denervation involved in regulation of muscle adaptation; response to drug; response to interleukin-1; skeletal system development
Reference #:  Q6NZM9 (UniProtKB)
Alt. Names/Synonyms: 4932408F19Rik; AI047285; HD4; Hdac4; Histone deacetylase 4
Gene Symbols: Hdac4
Molecular weight: 118,562 Da
Basal Isoelectric point: 6.43  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint  |  NF-kB Signaling  |  Protein Acetylation  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene