PHIP Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization. Expressed in myeloma and epidermoid carcinoma cell lines. Note: This description may include information from UniProtKB.
Chromosomal Location of mouse Ortholog: 9|9 E2
Cellular Component:  nucleus
Molecular Function:  insulin receptor binding; lysine-acetylated histone binding; protein binding
Biological Process:  cell population proliferation; cytoskeleton organization; fibroblast proliferation; insulin receptor signaling pathway; negative regulation of apoptotic process; negative regulation of extrinsic apoptotic signaling pathway; peptidyl-serine phosphorylation; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of fibroblast proliferation; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of mitotic nuclear division; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-threonine phosphorylation; positive regulation of transcription by RNA polymerase II; positive regulation of type B pancreatic cell proliferation; protein import into nucleus; regulation of cell morphogenesis; regulation of cell shape; regulation of growth; regulation of protein phosphorylation; regulation of transcription by RNA polymerase II; type B pancreatic cell proliferation
Reference #:  Q8VDD9 (UniProtKB)
Alt. Names/Synonyms: 2810004D21Rik; 4632404O06Rik; IRS-1 PH domain-binding protein; NDRP; neuronal differentiation related protein; Neuronal differentiation-related protein; PH-interacting protein; PHIP; Phip1; pleckstrin homology domain interacting protein; WD repeat domain 11; WD repeat-containing protein 11; Wdr1; Wdr11
Gene Symbols: Phip
Molecular weight: 206,726 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene