POP1 Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP. Defects in POP1 may be the cause of a severe skeletal dysplasia reminiscent of anauxetic dysplasia. Affected individuals show severe growth retardation of prenatal onset, a bone dysplasia affecting the epiphyses and metaphyses of the long bones particularly in the lower limbs, and abnormalities of the spine including irregularly shaped vertebral bodies and marked cervical spine instability. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.26.5; Nucleolus; RNA processing; Ribonuclease
Chromosomal Location of Human Ortholog: 15|15 B3.1
Cellular Component:  nucleolar ribonuclease P complex; nucleolus; ribonuclease MRP complex
Molecular Function:  ribonuclease MRP activity; ribonuclease P activity
Biological Process:  RNA phosphodiester bond hydrolysis, endonucleolytic; tRNA 5'-leader removal; tRNA catabolic process; tRNA processing
Reference #:  Q9D4G5 (UniProtKB)
Alt. Names/Synonyms: 4932434G09Rik; MGC36536; Pop1; processing of precursor 1; Processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae); processing of precursors 1; ribonucleases P/MRP protein subunit homolog
Gene Symbols: Pop1
Molecular weight: 114,028 Da
Basal Isoelectric point: 9.45  Predict pI for various phosphorylation states
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POP1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene