PRPF31 Involved in pre-mRNA splicing as component of the spliceosome. Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. Belongs to the PRP31 family. Ubiquitously expressed. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of mouse Ortholog: 7|7 A1
Cellular Component:  Cajal body; MLL1 complex; nuclear speck; nucleus; spliceosomal complex; U2-type precatalytic spliceosome; U4 snRNP; U4/U6 x U5 tri-snRNP complex; U4atac snRNP
Molecular Function:  ribonucleoprotein complex binding; RNA binding; snRNP binding; U4 snRNA binding; U4atac snRNA binding
Biological Process:  mRNA processing; mRNA splicing, via spliceosome; ribonucleoprotein complex localization; RNA splicing; spliceosomal tri-snRNP complex assembly
Reference #:  Q8CCF0 (UniProtKB)
Alt. Names/Synonyms: 1500019O16Rik; 2810404O06Rik; AW554706; OTTMUSP00000027355; pre-mRNA processing factor 31; Pre-mRNA-processing factor 31; Protein 61K; Prp31; PRP31 pre-mRNA processing factor 31 homolog; PRP31 pre-mRNA processing factor 31 homolog (yeast); Prpf31; RP11; U4/U6 small nuclear ribonucleoprotein Prp31; U4/U6 snRNP 61 kDa protein
Gene Symbols: Prpf31
Molecular weight: 55,430 Da
Basal Isoelectric point: 5.55  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene